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Solid Form Screening

 

For selected references describing PIHn in action see:

Price, C. P.; Grzesiak, A. L.; Matzger, A. J., “Crystalline Polymorph Selection and Discovery with Polymer Heteronuclei” J. Am. Chem. Soc. 2005, 127, 5512-5517.

Porter III, W. W.; Elie, S. C.; Matzger, A. J., “Polymorphism in Carbamazepine Cocrystals” Cryst. Growth Des., 2008, 8, 14-16.

López-Mejías, V.; Kampf, J. W.; Matzger, A. J. “Polymer-Induced Heteronucleation of Tolfenamic Acid: Structural Investigation of a Pentamorph” J. Am. Chem. Soc. 2009, 131, 4554-4555.

Roy, S.; Matzger, A. J., “Unmasking a Third Polymorph of a Benchmark Crystal Structure Prediction Compound” Angew. Chemie Int. Ed. Engl., 2009, 48, 8505-8508.

The search for new solid forms of existing materials offers the potential to perturb properties such as solubility without additional synthesis and the associated costs and regulatory scrutiny. This is especially true in the area of pharmaceutical polymorphism, where performance and intellectual property concerns motivate the discovery of all energetically accessible arrangements of an API. We are the only company holding a license on the technique of polymer-induced heteronucleation (PIHn). PIHn is the only polymorph discovery technique invented in the last 100 years that has a proven track record of accessing new forms. We offer polymorph screening solutions ranging from supplying polymer plates to applying PIHn to your molecules through complete in house screening of your molecule of interest.

Contact us to discuss your solid form screening needs and how ChemXLerate can be your partner in navigating polymorph space.

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